Health Enhancer Anabolic Steroids Women, Female Muscle Steroids Drospirenone

Posted by admin_user On May - 16 - 2019

Health Enhancer Anabolic Steroids Women, Female Muscle Steroids Drospirenone oral contraceptive

Health Enhancer Anabolic Steroids Women, Female Muscle Steroids Drospirenone

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Basic information

Detail

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Specification

CAS

67392-87-4

Formula

K19X26O3

Molecular weight

366.49

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Description

Drospirenone (HOTEL, USAN), also known as dihydrospirorenone 1,2, is a steroidal progestin of the spirolactone group used in birth control pills and postmenopausal hormone replacement therapy pills.

It is marketed as a combined oral contraceptive under the brand names Yasmin (USA, EU, Latin America), Jasmine (France), Yarin (Canada) [2] in a dosage containing µg drospirenone 3 mg / ethynylestradiol 30. In the United States , Baer Schering has released a pill based on Yasmine with Vitamin B (B9) folate, which is marketed under the names Safiral and Bayaz.

It is also sold globally under the brand names Yaz and Yasminelle at a lower dosage containing 3 mg drospirenone µg / ethynylestradiol 20.

Medical uses

Drospirenone is an ingredient in certain pills and hormone replacement therapy for birth control. In combination with estradiol ethyl it is used as contraception, and for women who want contraception it is also approved by the US Food and Drug Administration (FDA) to treat mild acne and premenstrual dysphoric disorder..

Negative influences

Drospirenone is an aldosterone antagonist with potassium-sparing properties, although in most cases no increase in potassium winadrol review levels can be expected. In women with mild or moderate renal impairment, or in combination with chronic daily use of other drugs, potassium sparingly (ACE inhibitor, angiotensin II receptor antagonists, potassium durethix sparing, heparin, aldosterone antagonists, or NSAIDs), the potassium level should to be checked after 2 weeks of use to test for hyperkalemia. In addition to counterindications common to all estrogen-progestin combined medications, drospirenone-containing medications are counterindicated in women with severe renal failure according to the European Medicines Agency (EMA) – approved labels, and counterindicated in women with renal insufficiency, adrenal insufficiency, or diseases Food and Drug Administration-Approved Labels.

Women who take birth control pills containing drospirenone have a 6 to seven times the risk of developing thromboembolism (dangerous blood clots) compared to women who take no birth control pill, and have twice the risk (some epidemiological studies suggest three times, according to the FDA for quality PRODUCTS AND MEDICINES) compared to women who take a contraceptive pill containing levonorgestrel, although the actual risk is small, in the neighborhood of 9 to 27 out of 10,000 women on oral contraceptive for a year (up to 9 for levonorgestrel versus up to 27 for drospirenone, or about 0.09% versus 0.3% per year.)

While all oral contraceptives may increase the risk for venous thromboembolic events, including fatal blood clots, several studies report a greater risk for women taking contraceptives containing drospirenone. (Before being alarmed at the huge “relative” differences in risk, it must be remembered that the “actual” risks involved, which are quite small – in the neighborhood of 1 in 10,000 to 27 in 10,000 per year).

When the US Food and Drug Administration (FDA) became concerned about the risks of drospirenone, they funded research based on the medical histories of more than 800,000 women taking oral contraceptives. They found that the risk of VTE, which includes dangerous and potentially fatal blood clots, was 93% higher for women who took oral contraceptives made with drospirenone for only 3 months or less and 290% higher for women taking oral contraceptives made with drospirenone at 7 – 12 months, compared to women taking other types of oral contraceptives. Further research is warranted to determine the exact risk for women of different ages and different circumstances..

The FDA recently updated a contraceptive label containing drospirenone to include warnings for stopping use before and after surgery, and to warn that contraceptives with drospirenone may have a higher risk of dangerous blood clots.

Pharmacology

Pharmacodynamics

Drospirenone binds strongly to a progesterone receptor (PR) and a mineralocorticoid receptor (MR), with a lower affinity for an androgen receptor (AR), and a very low affinity for a glucocorticoid (GR) receptor. It is an agonist of PR and an antagonist of G-NA and AR, and therefore a progestogen, antimineralocorticoid, and antiandrogen. Drospirenone is said to be devoid of all estrogenic or glucocorticoid or antiglucocorticoid activity. It has a potent antigonadotropic effect at sufficient dosages as a result of PR activation. Drospirenone has been considered to have a pharmacological profile that is very closely related to this of natural progesterone, due to the combination of both the progestogenic and anti-mineralocorticoid action.

Drospirenone is 8-10 times more potent as an anti-mineralocorticoid in relation to spironolactone (drospirenone 3 mg is equivalent to about 20-25 mg spironolactone in this respect). It is more potent as an antiandrogen in relation to spironolactone as well but less potent in relation to cyproterone acetate, having about one-third the power of this drug. Progestogenic, anti-mineralocorticoid, and weak antiandrogenic effects have been observed in humans during treatment with drospirenone at a dosage range of 0.5 to 4 mg per day orally.

Antimineralocorticoid properties shown by drospirenone to increase sodium excretion and prevent water retention.

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Pharmacokinetic

Health Enhancer Anabolic Steroids Women, Female Muscle Steroids Drospirenone oral contraceptives

Drospirenone is taken orally with about 76% bioavailability. It is bound not by sex hormone-binding globulin or corticosteroid binding globulin, but by other serum proteins. Metabolites have not been shown to be biologically active, show up in urine and feces, and substantially excrete metabolites within 10 days.

Chemistry

Analogue to spironolactone, with a molecular weight of 366.5 and a gross formula of K24X30O3.

Education

A mixture of some of the newer oral contraceptive formulations:

Yasmine / Jamine / Yarina contains 3 mg drospirenone and 30 mcg ethinylestradiol per tablet. Indicated for the prevention of pregnancy in women who choose oral contraceptives.

Safyral contains 3 mg drospirenone and 30 mcg ethynylestradiol per tablet. Indicated for the prevention of pregnancy in women who choose oral contraceptive as well as providing a daily dose of folate supplementation, which is recommended for women in their reproductive Folate Years reduces the risk of having rare neural tube defects in pregnancy occurring during use of Safiral or shortly after stopping.

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In January 2011, the KBK TV program market ran a stage discussing issues that included the use of Yaz / Yasmin.

In July 2012, Baer informed its shareholders that there were more than 12,000 lawsuits against the company including Yaz, Yasmin, and other oral contraceptives with drospirenone, and that the company then set 1,977 cases for $ 402.6 million, for an average of $ 212,000 per case. while setting aside $ 610.5 million to set others.

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